Season 1[]
- Belita Moreno as Ronnie Gardner ("Our Very First Promo")
- Phyllis Diller as herself ("But Seriously, Folks")
- Kirk Cameron as Cousin Steve, Danny's nephew and the girls' cousin (also Kimmy's crush) ("Just One of the Guys")
- Chelsea Noble as Jesse's girlfriend, Samantha ("The Seven-Month Itch (Part 1)")
Season 2[]
- Jonathan Brandis as Michael Monford ("A Little Romance")
- The Beach Boys as themselves ("Beach Boy Bingo")
Season 3[]
- Doris Roberts as Claire Tanner ("Granny Tanny")
- Scott Baio as Pete Bianco ("Dr. Dare Rides Again")
- The Beach Boys as themselves ("Our Very First Telethon")
- Raiderettes as "The Cheerleaders" ("Our Very First Telethon")
Season 4[]
- Wayne Newton as himself, when Joey opens for him in Las Vegas ("Viva Las Joey")
- Erika Eleniak as Jesse's high school girlfriend Carrie Fowler ("One Last Kiss")
- Jaleel White as his character Steve Urkel from the series Family Matters ("Stephanie Gets Framed")
- Frankie Avalon as himself ("Joey Goes Hollywood")
- Annette Funicello as herself ("Joey Goes Hollywood")
Season 5[]
- June Lockhart as Miss Wiltrout ("Double Trouble" and "Matchmaker Michelle")
- David Lascher as Rick ("Take My Sister, Please")
- Whitman Mayo as Eddie Johnson ("The Volunteer")
- Tommy Page as himself ("Crushed")
- The Beach Boys as themselves ("Captain Video (Part 1)")
Season 6[]
- Danielle Fishel as Jennifer P. ("I'm Not D.J." and "Silence is Not Golden")
Season 7[]
- Marla Sokoloff as Gia Mahan ("Fast Friends") (later became a recurring role)
- Ben Stein as Elliott Warner ("Another Opening, Another No Show")
- Vanna White as herself and Mrs. Moffatt ("The Test")
- Beverly Archer as Ms. Twitchel ("The Test")
- Suzanne Somers as herself ("Love on the Rocks")
- Little Richard as himself and Denise Frazer's uncle ("Too Little Richard Too Late")
Season 8[]
- Andrea Abbate as Gia's mother Claire Mahan ("Making Out is Hard to Do") and Danny's new girlfriend ("Claire and Present Danger")
- Barry Williams as himself, replacing Jesse as lead singer of The Rippers ("Making Out is Hard to Do")
- David Ruprecht as TV host [in Jesse's nightmare] ("Making Out is Hard to Do")
- Mickey Rooney as Mr. Dreghorn ("Arrest Ye Merry Gentlemen")
- Frankie Valli as himself ("D.J.'s Choice")
- Kareem Abdul-Jabbar as himself ("Air Jesse")