- "It's Not My Job" (2.3)
- "Our Very First Christmas Show" (2.9)
- "A Little Romance" (2.11)
- "Fogged In" (2.12)
- "El Problema Grande de D.J." (2.17)
- "Goodbye Mr. Bear" (2.18)
- "The Wedding (Part 2)" (4.19)
- "Wedding or Not Here We Come" (3.9)
During his young adulthood he began to own a business, in which he is a bug exterminator. He met his wife, Irene, the day that Elvis was drafted and they later fell in love and got married and later gave birth to a son named Jesse Katsopolis and a daughter named Pamela Tanner. Nick was a strict but loving father. In the episode, "D.J. Tanner's Day Off" it is mentioned that he would punish Jesse severely, and became the inspiration for the "Dad face" in said episode. This combination is also seen in the episode "It's Not My Job" when Jesse quits the extermination business Nick responds with: "If you're out of the business, you're out of the family." Later on, he explains this by saying that he did not build up the business to sell it to a stranger. Also, his love for his family is shown by the fact that Irene bringing in Michelle curbed his anger. When Michelle was getting ready to do a TV commercial for marshmallows ("El Problema Grande de D.J."), he remarked that Michelle looked like a little blonde version of the redhead (Ginger) that he likes on the TV show Gilligan's Island.
In "Fogged In", when he and Irene stay over at the Tanner house after a huge fog covered San Francisco, he got into the dispute over whether or not Danny should let D.J. have a drum set; thus, Danny thinks this is where Jesse gets his "buy-off" behavior from. At the end of the episode, during his chat with D.J., Jesse himself mentions that Nick used to buy him off with a Batman comic book to settle a dispute or problem.